Effect of Low Dose Aspirin Administration in Idioipathic Alpha-fetoprotein Elevation

Abstract

Objective: This study aims to evaluate the outcome of low-dose aspirin administration in complicated pregnancies with idiopathic alpha-fetoprotein (AFP) elevation. Methods: In this randomized controlled trial, 200 participants with singleton pregnancies presenting with idiopathic elevated alpha-fetoprotein (AFP>2 multiples of the median (MoM)) were recruited. Patients in their 16^th to 20^th week underwent ultrasonography and Doppler imaging as diagnostic tests. Based on the results of the diagnostic tests, patients were divided into two groups. Normal uterine artery Doppler group (N=100) and Abnormal group(N=100). patients divided into two groups in terms of aspirin intake. Primary complications included preterm delivery, fetal death, intrauterine growth restriction (IUGR), preeclampsia and neonatal hospitalization. Results: From May 2015 through June 2016, 200 women were randomized as follows: 100 to 80 mg ASA tab; 100 to no treatment. Most characteristics were similar across groups. The risk of the IUGR was 2% versus 14% p-value: 0.027, the risk of preterm labor and Neonatal hospitalization were also less, but the risk of IUFD and preeclampsia did not change. Conclusion: Administration of low dose of aspirin can have prophylactic effects against some adverse outcomes in complicated pregnancies presenting with elevated alpha-fetoprotein levels.